Membrane engineering of S. cerevisiae targeting sphingolipid metabolism

Membrane engineering of S. cerevisiae targeting sphingolipid metabolism

The sustainable production of fuels and chemicals using microbial cell factories is now well established. However, many microbial production processes are still limited in scale due to inhibition from compounds that are present in the feedstock or are produced during fermentation. Some of these inhibitors interfere with cellular membranes and change the physicochemical properties of the membran...

Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae.

We had previously isolated the temperature-sensitive erg26-1 mutant and characterized the sterol defects in erg26-1 cells (Baudry, K., Swain, E., Rahier, A., Germann, M., Batta, A., Rondet, S., Mandala, S., Henry, K., Tint, G. S., Edlind, T., Kurtz, M., and Nickels, J. T., Jr. (2001) J. Biol. Chem. 276, 12702-12711). We have now determined the defects in sphingolipid metabolism in erg26-1 cells...

Inborn errors of sphingolipid metabolism.

I T is my intent to gather together facts pertaming to the lipidoses which might serve to focus on current problems and to call attention to possible therapeutic approaches. The particular lipidoses to be discussed involve the accumulation in tissues of sphingolipids and may be referred to as sphingolipidoses. They may be classified as “inborn errors of sphingolipid metabolism” on the basis tha...

Membrane Engineering: Future Perspectives

Analysis of sphingolipid-signaling at the plasma membrane of Saccharomyces cerevisiae

Analysis of sphingolipid-signaling at the plasma membrane of Saccharomyces cerevisiae vorgelegt von Florian Fröhlich 2010 Eherenwörtliche Versicherung Ich versichere hiermit ehrenwörtlich, dass die vorgelegte Dissertation von mir selbstständig und ohne unerlaubte Hilfe angefertigt ist. Erklärung Hiermit erkäre ich, Dass die Dissertation nicht ganz oder in wesentlichen Teilen einer anderen Prüfu...